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Toulon clinched a first ever win over Clermont at the Stade Marcel Michelin in emphatic fashion with a 35-9 victory on Saturday.
Brive, Bordeaux-Bègles and Castres all picked up wins in the Top 14’s afternoon matches on Saturday, with Brive climbing to fourth.
Connacht continued their stay at the top of PRO12 with an 18-12 win over Irish rivals Munster.
Wasps left it late but came away from Twickenham with a bonus point victory over London Irish, producing a 33-15 win.
Ospreys took the bragging rights from Saturday’s Welsh derby with a tense 13-6 win over Cardiff Blues.
Exeter Chiefs and Harlequins were separated by a single point in a 26-25 win for the home side at Sandy Park.
Saracens made it seven wins out of seven this season with a dominant display against Worcester at Twickenham, winning 48-18.
Danny Cipriani missed a last minute penalty as Sale Sharks were made to settle for a 15-15 draw against Newcastle Falcons on Saturday.
Racing 92 moved up to second in the Top 14 standings after they defeated Toulouse 28-13 at Stade Yves du Manoir on Saturday.
Sale have made an enforced change to their starting line-up as TJ Ioane comes in for Josh Beaumont who is ruled out with an injury.